![]() The findings may help the health care professionals to substantiate the possible improvement in glucose metabolism and HRQoL potentially achieved by lifestyle changes, and better convince people at high risk of T2D to take action towards healthier lifestyle habits. Overall, old age, lack of physical activity, obesity, and history of high blood glucose were the FINDRISC factors most prominently associated with lower HRQoL. The association between HRQoL and the risk of developing T2D was also observed for most dimensions of HRQoL in all applied HRQoL instruments. An approximate 4-5 point change in FINDRISC score was observed to be associated with clinically noticeable changes in the preference-based instrument HRQoL index scores. Low HRQoL was significantly and directly associated with the estimated risk of developing T2D. Effects of the individual FINDRISC items and demographic and clinical characteristics, such as co-morbidities, on HRQoL were studied using multivariable Tobit regression models. The risk of developing T2D was assessed using the validated and widely used FINDRISC (range 0-26 points), and quality of life was measured using two preference-based HRQoL instruments (15D and SF-6D) and one health profile instrument (SF-36). We conducted a cross-sectional study comprising 707 Finnish people without a diagnosis of T2D between the ages of 51 and 75 years. We quantify the association between Finnish Diabetes Risk Score (FINDRISC) and HRQoL, and examine the potential use of FINDRISC as tool to evaluate HRQoL indirectly. Present study examines the relationship between the estimated risk of developing type 2 diabetes (T2D) and health-related quality of life (HRQoL). The results obtained might be applied in the development of algorithms of correction of comorbidities in primary healthcare. In the groups of high and very high CVR the HFG was most common, but concomitance of HFG with GI two times less common. Áhence the increase of CVR is associated with foretime increase of DM risk. ![]() Among moderate CVR patients - every tenth, with high CVR every third, and in the group with very high CVR - every second had severe risk of DM development by FINDRISC. Among high CVR persons by SCORE the prediabetes was found in 40% cases, and in the group of not very high risk almost in every second had HFG, and concomitance of HFG and GI - 15,2% cases. In the group of men with lower and moderate CVR prediabetes was diagnosed in 21% cases. In 28,3% of men there was HFG, its comorbidity with GI was found only in 12,3%. Early disorders of glucose metabolism were found as high fasting glycaemia (HFG), glucose intolerance (GI) and their comorbidity. Early disorders of carbohydrate metabolism were defined with fasting glucose level and in 2 hours after load of 75 g of glucose. Methods of study included questionnaires, standard clinical, instrumental and laboratory studies. Totally, 300 men included, age 40-59 with one or more risk factors. To assess the early disorders of carbohydrate metabolism and risk of diabetes development (DM) among males with different level of cardiovascular risk (CVR) by SCORE.
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